From GenoSeq

Sugandha Dandekar (Uma)

Assistant Director, GenoSeq Core, UCLA Human Genetics Department

Education:

B.S. Government Polytechnic, Goa, India (1982-1987)

Professional History:

Assistant Director, GenoSeq Core (2006-Present)

Manager, GenoSeq Core, (2002-2005)

Research Associate, GenoSeq Core, (2001-2002)

Led High throughput genotyping projects

Research Associate, Department of Medicine-Hematology/Oncology, UCLA School of Medicine (1996-2001)

Used physical mapping to detect amplicons in breast cancer tissues and other cancers

Fluorescent in situ hybridized HER-2/neu in cancer tissues

Laboratory Assistant, Department of Pathology, UCLA School of Medicine (1992-1995)

Genotyped ataxia telangiectasia (ATM) gene on human chromosome 11q23.1

Sequenced ATM

Positional cloned ATM

Publications:

Andrew J Levine, Elyse J Singer, Janet S Sinsheimer, Charles H Hinkin, Jeanette Papp, Sugandha Dandekar, Allison Giovanelli, Paul Shapshak CCL3 genotype and current depression increase risk of HIV-associated dementia.Neurobehavioral HIV Medicine 2009 Volume 1

Vaithilingaraja Arumugaswami, Ronika Sitapara, Seungmin Hwang, Moon Jung Song, Tuyet Ngoc Ho, Nancy Qi Su, Eric Y Sue, Vidhya Kanagavel, Fangfang Xing, Xiaolin Zhang, Minglei Zhao, Hongyu Deng, Ting-Ting Wu, Sudhakar Kanagavel, LuLu Zhang, Sugandha Dandekar, Jeanette Papp, and Ren Sun*. High-resolution Functional Profiling of a Gammaherpesvirus RTA Locus in the Context of the Viral Genome.J. Virol. doi:10.1128/JVI.02302-08.

Konecny GE, Thomssen C, Luck HJ, Untch M, Wang HJ, Kuhn W, Eidtmann H, du Bois A, Olbricht S, Steinfeld D, Mobus V, von Minckwitz G, Dandekar S, Ramos L, Pauletti G, Pegram MD, Janicke F, Slamon DJ. Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer. J Natl Cancer Inst. 2004 Aug 4;96(15):1141-51.

Konecny G, Pauletti G, Pegram M, Untch M, Dandekar S, Aguilar Z, Wilson C, Rong HM, Bauerfeind I, Felber M, Wang HJ, Beryt M, Seshadri R, Hepp H, Slamon DJ. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J Natl Cancer Inst. 2003 Jan 15;95(2):142-53.

Pauletti G, Dandekar S, Rong H, Ramos L, Peng H, Seshadri R, Slamon DJ. Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: A direct comparison of fluorescence In situ hybridization and immunohistochemistry. J Clin Oncol 18(21):3651-64 2000.

Udar N.S., Xu S., Bay J-O, Dandekar S., Patel N., Chen X., Liang T., Uhrhammer N., Klisak I., Shizuya H., Yang H., Samara G., Nelissen J., Sawicki M., Concannon P., Gatti R. Physical map of the region surrounding the Ataxia-Telangiectasia gene on human chromosome 11q22-23. Neuropediatrics. 1999 Aug;30(4):176-80. Review.

Xiaoguang Chen, Lan Yang, Nitin Udar, Teresa Liang, Nancy Uhrhammer, Shunbin Xu, Jacques-Olivier Bay, Zhijun Wang, Sugandha Dandekar, Sujata Chiplunkar, Ivana Klisak, Milhan Telatar, Huanming Yang, Patrick Concannon, Richard A Gatti. CAND3, a gene weakly homologous to Oct-1 and cdc25 and immediately proximal to the ATM gene at 11q23.1. Mammalian genome 8:129-133 1997.

Uhrhammer N., Dandekar S., et al. Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families. Amer J Hum Genet 57:103-111 1995.

Lange E., Dandekar S., et al. Localization of an ataxia- telangiectasia gene to a ~500 kb interval on chromosome 11q23.1: linkage analysis of 176 families in an international consortium. Amer J Hum Genet. 57:112-119 1995.

Gatti RA., Dandekar S., et al. Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an ~850 kb region on chromosome 11q23.1. Int. J. Radiat. Biol. 66:S57-S62 1994.

Papers Presented:

A preliminary study using high-resolution melting for CpG- site methylation status. ASHG, San Diego, October 2007.

A gene rich region around the ATM locus - Physical map and identification of two new transcripts in the 11q23.1 region. 6th International Identification of Transcribed sequence workshop, Edinburg, UK October 3-5th.

A New PCR Protocol for getting Full length sequence of cDNA. International Transcribed Sequence Workshop, Marseilles, France November, 1995.

Comparative evaluation of techniques for capturing transcribed sequences. 4th International Workshop on the Identification of Transcribed Sequences, Montreal, Quebec October 16-18, 1994.

Selection of simple tandem repeats (STR’s) - A rapid technique using superparamagnetic beads. 44th Annual meeting of the American Society of Human Genetics, Montreal, Quebec October 18th, 1994.

STR primer extension: an efficient method for isolating short tandem repeats 43rd Annual meeting of the American Society of Human Genetics, New Orleans, Louisiana October 5-9, 1993.

A new method for screening cDNA libraries for repeat sequences. 43rd Annual meeting of the American Society of Human Genetics, New Orleans, Louisiana October 5-9, 1993.